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  • Crinetics presented up to two-year PATHFNDR-1/2 data confirming PALSONIFY maintains durable acromegaly biochemical control.
  • IGF-1 levels remained stable and acromegaly symptoms were controlled across patients.
  • PALSONIFY stabilized or reduced pituitary tumor volume in the extension studies.
  • Patients switched from injectable therapies and previously untreated patients both showed durable responses.
  • Combining PALSONIFY with cabergoline improved biochemical control versus PALSONIFY alone.
  • No new safety signals were reported, supporting tolerability and market relevance of oral paltusotine.

Latest Articles

U.S. Administration Proposes Broad Tariffs Targeting Forced-Labor Imports

U.S. Administration Proposes Broad Tariffs Targeting Forced-Labor Imports

The administration of President Donald Trump has introduced a proposal for significant new tariffs aimed at imports from 60 different economies. This move follows investigations by the Office of the U.S. Trade Representative (USTR) which determined that certain trading partners have failed to prevent the entry of goods produced via forced labor, an…

Yen Approaches 160 Threshold as Japanese Officials Signal Potential Intervention

Yen Approaches 160 Threshold as Japanese Officials Signal Potential Intervention

The Japanese yen has experienced significant weakness, briefly breaching the 160 per dollar mark during early trading sessions. This movement represents the first time the currency has touched this level since April 30, effectively erasing the progress made by previous massive foreign exchange interventions. As market participants await a scheduled…

Cambodia Invokes Little-Used UN Procedure to Press Maritime Claim Against Thailand

Cambodia Invokes Little-Used UN Procedure to Press Maritime Claim Against Thailand

Cambodia has opened a compulsory conciliation procedure under the United Nations Convention on the Law of the Sea (UNCLOS) to address a long-standing maritime boundary contest with Thailand. The disputed area, roughly 26,000 square kilometres in the Gulf of Thailand, is estimated to contain about 12 trillion cubic feet of natural gas and substantia…

Yen Tests 160 per Dollar as Markets Watch for Possible Tokyo Intervention

Yen Tests 160 per Dollar as Markets Watch for Possible Tokyo Intervention

The Japanese yen traded close to the critical 160-per-dollar threshold on Wednesday, briefly touching the level that prompted intervention in April. The currency is under pressure as investors price in prolonged higher U.S. interest rates and Japan absorbs higher energy costs. Officials have reiterated their willingness to act, and market focus has…

Josh Turek Clinches Democratic Nomination in Iowa Senate Primary

Josh Turek Clinches Democratic Nomination in Iowa Senate Primary

Iowa State Representative Josh Turek captured the Democratic nomination for the U.S. Senate on Tuesday, earning a path to the November general election where he will oppose Republican Representative Ashley Hinson for the open seat vacated by retiring Senator Joni Ernst. Early returns showed Turek leading decisively in the primary, while analysts co…

Supreme Court Allows Alabama to Implement Republican-Favored Congressional Map

Supreme Court Allows Alabama to Implement Republican-Favored Congressional Map

The U.S. Supreme Court on June 2 cleared the way for Alabama to deploy a congressional map backed by Republican legislators that would eliminate one of two districts where Black voters form a majority or near-majority. The decision, issued over the dissent of the court's three liberal justices, stayed a federal three-judge panel's order that had bl…

Director's Activity at WhiteHorse Finance Signals Mixed Investor Sentiment

Director's Activity at WhiteHorse Finance Signals Mixed Investor Sentiment

WhiteHorse Finance director John Paul Volpe recently purchased an additional 1,000 shares of the company's common stock. This transaction occurred on May 29, 2026, and was reported to the public on June 2, 2026. The report follows the release of WhiteHorse Finance's first quarter 2026 financial results, which revealed both earnings per share (EPS) …

Ueda Set to Address Policy Outlook Amid Intensifying Calls for June Rate Hike

Ueda Set to Address Policy Outlook Amid Intensifying Calls for June Rate Hike

Bank of Japan Governor Kazuo Ueda is scheduled to deliver a critical speech on Wednesday that is expected to provide insight into the central bank's potential trajectory for interest rate adjustments. The address comes at a period of heightened economic sensitivity, as escalating fuel expenses stemming from the Iran war continue to apply upward pre…

Ondas CEO Sells Stock After RSU Vesting; Company Secures Major Contracts

Ondas CEO Sells Stock After RSU Vesting; Company Secures Major Contracts

Chairman, CEO, and President Eric A. Brock sold company stock valued at approximately $31.9 million over two days in June 2026. This disposition was linked to tax withholding obligations associated with the vesting of his Restricted Stock Units (RSUs). Meanwhile, Ondas Inc. reported securing substantial new orders totaling over $110 million for the…