Press Releases June 4, 2026 04:31 PM

Eledon Announces Presentation of Updated Data from Investigator-Initiated Islet Transplant Trial of Tegoprubart in Patients with Type 1 Diabetes at American Diabetes Association (ADA) 2026 Scientific Sessions

Eledon Pharmaceuticals to present updated clinical trial data on tegoprubart in type 1 diabetes at ADA 2026

By Leila Farooq ELDN

Eledon Pharmaceuticals announced that updated results from an investigator-initiated trial of tegoprubart, their lead anti-CD40L antibody, will be presented at the 2026 American Diabetes Association Scientific Sessions. The trial focuses on islet transplantation in type 1 diabetes patients, exploring immune-modulatory therapies to improve graft survival and function. This presentation highlights progress in Eledon's clinical development of immune therapies targeting CD40L in transplantation and other diseases.

Eledon Announces Presentation of Updated Data from Investigator-Initiated Islet Transplant Trial of Tegoprubart in Patients with Type 1 Diabetes at American Diabetes Association (ADA) 2026 Scientific Sessions
ELDN

Key Points

  • Updated clinical trial data on tegoprubart, an anti-CD40L antibody, will be presented at ADA 2026, underscoring ongoing clinical progress.
  • The trial focuses on islet allotransplantation for type 1 diabetes, a critical area in transplantation and immunotherapy.
  • Eledon is advancing its therapies targeting CD40L signaling, with broader applications in transplantation and neurodegenerative diseases like ALS.
  • Sectors impacted include biotechnology, healthcare, immunotherapy, and transplant medicine.

IRVINE, Calif., June 04, 2026 (GLOBE NEWSWIRE) -- Eledon Pharmaceuticals, Inc. (“Eledon”) (Nasdaq: ELDN) today announced that updated results from an investigator-initiated trial being conducted at the University of Chicago Medicine Transplant Institute will be presented by Piotr Witkowski, M.D., Ph.D., Director of the Pancreas and Islet Transplant Program at UChicago Medicine, at the American Diabetes Association 86th Scientific Sessions, taking place June 5-9, 2026, in New Orleans, Louisiana.

Details of the oral presentation are as follows:

Presentation Title: Anti-CD40L to Induce Graft Survival and Function in Islet Allotransplantation
Session: Immune Modulatory Strategies for Next-Generation Cell Therapies
Date: Sunday, June 7, 2026
Time: 2:30 p.m. – 3:00 p.m. CT
Room: 343 (Level 3)

About Eledon Pharmaceuticals and tegoprubart

Eledon Pharmaceuticals, Inc. is a clinical stage biotechnology company that is developing immune-modulating therapies for the management and treatment of life-threatening conditions. The Company’s lead investigational product is tegoprubart, an anti-CD40L antibody with high affinity for the CD40 Ligand, a well-validated biological target that has broad therapeutic potential. The central role of CD40L signaling in both adaptive and innate immune cell activation and function positions it as an attractive target for non-lymphocyte depleting, immunomodulatory therapeutic intervention. The Company is building upon a deep historical knowledge of anti-CD40 Ligand biology to conduct preclinical and clinical studies in kidney allograft transplantation, xenotransplantation, islet cell transplantation, liver transplantation and amyotrophic lateral sclerosis (ALS). Eledon is headquartered in Irvine, California. For more information, please visit the Company’s website at www.eledon.com.

Follow Eledon Pharmaceuticals on social media: LinkedIn; Twitter

Investor Contact:
Stephen Jasper
Gilmartin Group
(858) 525 2047
[email protected]

Media Contact:
Jenna Urban
CG Life
(212) 253 8881
[email protected]

Source: Eledon Pharmaceuticals


Risks

  • Clinical trial results may not demonstrate sufficient efficacy or safety, which could delay regulatory approvals or commercialization.
  • Dependence on investigator-initiated trials and third-party researchers may affect data robustness and timelines.
  • Competition within the immune modulation and transplantation therapy markets may impact Eledon's market share and adoption.

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