Press Releases April 9, 2026 08:00 PM

Spyre Therapeutics to Host Conference Call to Report SPY001 Part A Induction Topline Results from SKYLINE Trial in Moderate-to-Severe Ulcerative Colitis Patients on April 13, 2026

Spyre Therapeutics to announce topline results from Phase A SKYLINE trial for SPY001 in ulcerative colitis patients

By Avery Klein SYRE

Spyre Therapeutics will report topline induction results from Part A of its SKYLINE clinical trial evaluating SPY001 in moderate-to-severely active ulcerative colitis patients on April 13, 2026. Following the announcement, the company will hold a conference call and webcast to discuss the data. Spyre is a clinical-stage biotech focused on developing long-acting antibodies for inflammatory bowel disease and rheumatic diseases.

Spyre Therapeutics to Host Conference Call to Report SPY001 Part A Induction Topline Results from SKYLINE Trial in Moderate-to-Severe Ulcerative Colitis Patients on April 13, 2026
SYRE

Key Points

  • Spyre is conducting the SKYLINE trial to evaluate the efficacy of SPY001, an investigational therapy, in moderate-to-severe ulcerative colitis patients.
  • The announcement includes topline induction results for Part A of the trial, representing an important clinical milestone.
  • Spyre is pioneering long-acting antibodies targeting multiple pathways implicated in IBD and rheumatic diseases, aiming to improve care standards.

WALTHAM, Mass., April 10, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE), a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases, today announced it will report SPY001 Part A induction topline results from the SKYLINE trial in moderate-to-severely active ulcerative colitis patients on Monday, April 13, 2026. Following the announcement, the Company will host a conference call and webcast at 8:00am ET on Monday April 13, 2026 to discuss the results.

To access the live and archived webcast, please visit the Investor Relations page of Spyre’s website at https://ir.spyre.com/events-and-presentations.

About Spyre Therapeutics

Spyre Therapeutics is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (“IBD”) and rheumatic diseases. Spyre's pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.

For more information, visit Spyre's website at www.spyre.com.

For Investors:
Eric McIntyre, Spyre Therapeutics
SVP of Finance and Investor Relations
[email protected]

For Media:
Josie Butler, 1AB
[email protected]


Risks

  • Topline results might not meet efficacy or safety expectations, potentially impacting future development and regulatory approval.
  • The clinical trial is in early phases (induction Part A), so further studies will be needed to confirm efficacy and safety.
  • The biopharmaceutical sector faces high risks from clinical trial uncertainties, regulatory hurdles, and competitive landscape in IBD therapeutics.

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