Insider Trading February 26, 2026

Exelixis Executive Sells $2.13M in Stock as Firm Posts Mixed Q4 Results

Research and Development EVP Aftab Dana disposes of nearly 48,000 shares; company posts EPS beat but slight revenue shortfall amid analyst optimism on oncology program

By Maya Rios EXEL
Exelixis Executive Sells $2.13M in Stock as Firm Posts Mixed Q4 Results
EXEL

Aftab Dana, Executive Vice President for Research and Development at Exelixis, Inc. (NASDAQ: EXEL), sold 47,918 shares on February 24, 2026, for $44.50 per share, totaling $2,132,351. The transaction occurs while third-party analysis flags the stock as trading below its intrinsic value. Exelixis reported a fourth-quarter 2025 EPS beat but missed revenue expectations, and analysts reacted by adjusting price targets and reiterating favorable ratings supported by interest in the company's cancer drug zanzalintinib.

Key Points

  • Aftab Dana sold 47,918 shares of Exelixis on February 24, 2026, for $44.50 per share, totaling $2,132,351.
  • Exelixis reported Q4 2025 EPS of $0.97 versus a $0.80 consensus, while revenue of $598.66 million missed the $604.56 million expectation.
  • InvestingPro flags Exelixis as trading below intrinsic value with a P/E of 16.04 and assigns an "EXCELLENT" financial health score; analysts adjusted price targets and maintained positive ratings amid interest in zanzalintinib.

Transaction overview

Aftab Dana, who serves as Executive Vice President, Research and Development at Exelixis, Inc. (NASDAQ: EXEL), sold 47,918 shares of the company’s common stock on February 24, 2026, at a price of $44.50 per share. The proceeds from the sale totaled $2,132,351.

Position after the sale

Following the disposition, Dana directly holds 616,106 shares of Exelixis common stock. That total includes 414,043 shares that are issuable upon vesting of restricted stock units (RSUs) and performance stock units (PSUs) granted on March 31, 2025. In addition to direct ownership, Dana indirectly owns 5,835 shares through participation in the Exelixis, Inc. 401(k) Plan.

Valuation and company health

InvestingPro analysis referenced alongside the transaction indicates Exelixis is trading below its intrinsic value and reports a price-to-earnings ratio of 16.04. The platform also assigns Exelixis an "EXCELLENT" financial health score and places the company’s market value at $11.51 billion.

Recent financial results

Exelixis released fourth-quarter 2025 financial results that showed mixed performance. The company reported earnings per share (EPS) of $0.97, outperforming the consensus forecast of $0.80 by 21.25%. Revenue for the quarter was $598.66 million, falling short of the expected $604.56 million.

Analyst reactions and program developments

In response to the quarterly report, H.C. Wainwright raised its Exelixis price target from $52 to $54 while maintaining a Buy rating, citing the EPS beat and attributing it in part to lower-than-expected tax expenses. Citizens left its Market Outperform rating and $50 price target intact and highlighted optimism around Exelixis’s cancer candidate zanzalintinib. Discussion at the ESMO 2025 meeting was noted as reinforcing interest in the drug’s potential in metastatic colorectal cancer.

Context and implications

The insider sale, the third-party valuation signal, the mixed quarterly results, and the analyst commentary together present a multifaceted view of the company’s near-term profile. The transaction and the financial report each offer different lenses on investor sentiment and the market’s assessment of Exelixis’s operational and development trajectory.


Note: This article presents transaction details and company disclosures as reported.

Risks

  • Revenue miss in Q4 2025 relative to expectations - impacts biotech and broader healthcare equity valuations.
  • Insider share sale could be interpreted variably by investors - may influence market perception in biotechnology and mid-cap equities.
  • Reliance on clinical progress for zanzalintinib as a driver of sentiment - outcomes from development and regulatory discussions affect pharmaceutical markets.

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