Analyst Ratings February 6, 2026

RBC Sticks With Outperform on Ocular Therapeutix, Flags Large Upside If SOL-1 Succeeds

Analyst cites on-track SOL-1 pivotal trial, proprietary simulations and commercial hires amid recent share weakness and corporate developments

By Avery Klein OCUL
RBC Sticks With Outperform on Ocular Therapeutix, Flags Large Upside If SOL-1 Succeeds
OCUL

RBC Capital reiterated an Outperform rating and $30.00 price target on Ocular Therapeutix (OCUL), pointing to meaningful upside from the current share price and continued confidence in the upcoming SOL-1 pivotal readout. The firm highlighted recent share underperformance, proprietary trial modeling, a new commercial hire, and the company’s decision to begin two pivotal diabetic retinopathy studies. RBC quantified potential outcomes tied to SOL-1 results while noting downside if the trial fails. Other market activity includes management changes, a Phase 3 program for AXPAXLI and takeover interest reportedly from Sanofi.

Key Points

  • RBC Capital reiterated an Outperform rating and maintained a $30.00 price target on Ocular Therapeutix, implying substantial upside from the recent $9.26 share price.
  • RBC highlighted that OCUL shares are down roughly 26-28% year-to-date while the XBI biotech index is up about 2%, with technical indicators suggesting the stock is oversold.
  • The firm cited on-schedule SOL-1 pivotal trial readout, proprietary trial simulations, the appointment of a new Global Chief Commercial Officer, and initiation of two pivotal diabetic retinopathy studies as key supports for the bullish view - sectors impacted include biotechnology and healthcare markets.

RBC Capital reaffirmed its Outperform rating on Ocular Therapeutix (NASDAQ: OCUL) and kept a $30.00 price target on the shares, according to a research note released Friday. That price objective implies substantial upside from the stock’s recent trading level of $9.26, while analyst targets among peers span from $19 to $31.

The research note called out that OCUL has lagged the biotech exchange-traded landscape so far this year. The firm noted a roughly 28% year-to-date decline in OCUL shares versus a 2% gain in the XBI biotech index. InvestingPro data reflected a similar drop, listing the year-to-date change at -26.61%. RBC also observed that technical gauges, including the relative strength index, indicate the stock is in oversold territory.

RBC analyst Lisa Walter expressed continued conviction in the upcoming SOL-1 pivotal trial readout. The note said the SOL-1 study remains on schedule and that the broader long-acting tyrosine kinase inhibitor - TKI - drug class has produced encouraging Phase I/II results in wet age-related macular degeneration, supporting the rationale for SOL-1’s development program.

The firm cited several drivers underpinning its favorable stance. First, proprietary trial simulations conducted by RBC suggest SOL-1 could meet the firm’s expectations for the pivotal endpoint. Second, management has strengthened its commercial bench with the appointment of a new Global Chief Commercial Officer, which RBC views as an operational positive as the company advances retinal programs. Third, Ocular Therapeutix has initiated plans to start two pivotal studies in diabetic retinopathy ahead of the wet AMD readout, a strategic sequencing that the analyst views as noteworthy.

RBC quantified scenario outcomes tied directly to SOL-1 performance. If SOL-1 produces a 50% delta on the study’s primary endpoint, RBC projects potential upside in excess of 100% for OCUL shares. Conversely, the firm emphasized that a failed study would expose the stock to downside risk exceeding 30%.

Despite RBC’s optimism, InvestingPro analysis cited in the note flagged that the stock may be trading at a valuation that some models consider rich at current levels. The RBC report also points readers toward a more detailed Pro Research Report that includes additional analysis and ProTips for OCUL alongside coverage of over 1,400 U.S. equities.

The company has had a flurry of recent corporate developments that market participants are watching. Chief Financial Officer and Chief Operating Officer Donald Notman is on temporary medical leave, with Jason Robins serving as interim CFO in the meantime. Ocular Therapeutix also named David W. Robinson as Global Chief Commercial Officer as it progresses AXPAXLI, an investigational retina treatment currently enrolled in Phase 3 testing.

Separately, there are reports that Sanofi is preparing to increase a takeover offer after Ocular Therapeutix’s board declined a first bid of $16 per share. On the sell-side, TD Cowen reiterated a Buy rating with a $20 price target, which the firm said implies about 45% upside contingent on SOL-1 Phase III success. Citizens kept a Market Outperform rating with a $29 target and highlighted the importance of SOL-1 when comparing Axpaxli to the competing product Eylea.

Taken together, the analyst shop’s reiterated Outperform, the company’s pipeline sequencing and commercial hires, ongoing leadership changes, and takeover chatter have combined to create a period of heightened activity and potential inflection points for Ocular Therapeutix.

Risks

  • A failed SOL-1 pivotal study could produce downside in excess of 30% for OCUL shares - this risk directly affects biotech investors and market participants exposed to clinical trial outcomes.
  • Operational disruption from leadership changes - the temporary medical leave of the CFO/COO and an interim financial lead could create execution uncertainty for corporate and commercial initiatives within the healthcare sector.
  • Valuation concerns noted by InvestingPro suggest the stock may be elevated at current prices, posing market risk for equity holders if expectations embedded in analyst targets are not met - relevant to biotech and small-cap equity markets.

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