NEO February 17, 2026

NeoGenomics Q4 & FY 2025 Earnings Call - Clinical Momentum and RaDaR ST Launch Signal NGS-Driven Growth

Summary

NeoGenomics closed 2025 with record revenue and clear strategic momentum, driven by double-digit clinical growth and rapid NGS adoption. Management is pivoting deliberately from low-value, high-volume contracts toward higher-average‑revenue testing, while readying a full commercial push for RaDaR ST and banking on PanTracer liquid reimbursement to accelerate growth in 2027. The company is layering salesforce expansion, LIMS consolidation, and RCM actions to convert revenue growth into sustainable margin expansion.

The 2026 guide is conservative, reflecting MolDX timing uncertainty and modest near-term contributions from RaDaR ST and PanTracer LBx, but it bakes in accelerating adjusted EBITDA and a path to free cash flow positivity. Key execution risks remain MolDX approvals cadence, successful commercialization of MRD and liquid NGS, and operational execution of LIMS and lab efficiencies.

Key Takeaways

  • Q4 2025 revenue was $190.0 million, up 11% year‑over‑year; full year 2025 revenue was $727.0 million, up 10% versus 2024.
  • Clinical revenue grew 16% year‑over‑year in Q4, and full‑year clinical revenue increased 15% (13% ex PathLine).
  • NGS revenue jumped 23% in the quarter, and NGS now represents roughly one third of clinical revenue while accounting for only ~9%–10% of test volume.
  • Five NGS products launched since March 2023 contributed 22% of clinical revenue in Q4, showing strong uptake of newer offerings.
  • Management is executing a deliberate shift away from low‑AUP, high‑volume contracts, citing exit of a low‑value client with AUPs in the low $200s, and now prioritizing upper single‑digit AUP growth with lower single‑digit volume growth.
  • RaDaR ST: bridging data showed 97% concordance with RaDaR 1.0, enabling MolDX reimbursement for two indications (HPV‑negative head and neck, and a breast cancer subset); company plans a full clinical launch by month end.
  • NeoGenomics submitted two additional solid tumor indications for MolDX for RaDaR ST, which management says could roughly double the addressable patient opportunity if approved, but timing is uncertain and upside to 2026 guidance is not assumed.
  • 2026 guidance: revenue $793M–$801M (midpoint ~$797M), adjusted EBITDA $55M–$57M, with RaDaR ST assumed to deliver mid‑single‑digit millions in 2026 and PanTracer LBx modest contribution in 2H if reimbursed.
  • PanTracer portfolio: PanTracer Tissue showed strong repeat doubling of volumes (2023→2024 and 2024→2025); PanTracer Pro launched; PanTracer LBx (liquid) has been submitted to MolDX and is modeled conservatively toward 2H26 contribution.
  • PathLine acquisition expanded New Jersey presence and contributed to operations; PathLine is a short‑term drag on gross margin but expected to be accretive to profitability beginning in 2026.
  • Adjusted gross profit improved $5.8M in Q4 and adjusted EBITDA for Q4 was $13.4M, marking the 10th consecutive quarter of positive adjusted EBITDA; full‑year adjusted EBITDA rose to $43.4M, up 9%.
  • Cash and liquidity: Q4 cash balance $160M, cash flow from operations was positive $1M in Q4 and $5M for full year 2025; management expects to become free cash flow positive in 2026.
  • Management expects growth margin expansion of roughly 100–120 basis points in 2026, driven by pricing, RCM initiatives, and mix shift to higher‑value tests; adjusted EBITDA expected to grow ~27%–31% year‑over‑year.
  • LIMS consolidation from eight systems to one is underway, prioritized by modality and site; workflow and analytics benefits begin to show in late 2026, with more pronounced margin benefits in 2027–2028.
  • Pharma/biotech revenue (about 5%–6% of company revenue) is expected to decline modestly in 2026 in mid‑to‑upper single digits, with recovery targeted in 2027 and RaDaR ST seen as a key catalyst for reengagement.
  • Commercial execution: company added ~35 oncology sales specialists in late 2024/early 2025, plans adding more than 25 OSS by Q3 to support RaDaR ST and PanTracer LBx; initial dedicated ENT coverage deployed for HPV‑negative head and neck market.
  • Operational note: total test volumes rose 11% in Q4 while AUP grew 5% in the quarter and 7% same‑store (ex PathLine), reflecting pricing, managed care wins, and mix shift toward NGS and higher‑value assays.
  • Key risks: timing and scope of MolDX decisions for RaDaR ST and PanTracer LBx, successful commercialization of MRD and liquid NGS in community settings, and execution of LIMS and RCM projects to translate revenue into margin expansion.

Full Transcript

Kelly, Conference Call Operator: Good morning, and welcome to the NeoGenomics fourth quarter and full year 2025 financial results call. Please be advised that today’s conference is being recorded. I will now turn the call over to Kendra Webster with NeoGenomics. The floor is yours.

Kendra Webster, Investor Relations, NeoGenomics: Thank you, Kelly, and good morning, everyone. Welcome to the NeoGenomics fourth quarter and full year 2025 financial results call. With me today to discuss the results are Tony Zook, Chief Executive Officer, Jeff Sherman, Chief Financial Officer, and Abhishek Jain, EVP of Finance. Additional members of the management team will be available for the Q&A portion of our call. This call is being simultaneously webcast. For reference, concurrent with today’s call, we posted a short slide presentation to the Investors tab on our website at ir.neogenomics.com. During this call, we will make forward-looking statements regarding our future financial and business performance, business strategy, the timing and outcome of reimbursement decisions, and financial guidance. We caution you that the actual events or results could differ materially from those expressed or implied by the forward-looking statements.

These forward-looking statements made during the call speak only as of the original date of the call, and we undertake no obligation to update or revise any of these statements. Please refer to the information disclosed on the Safe Harbor Statements slide in the deck posted on our website, as well as the information under the heading Risk Factors in our most recent Forms 10-K, 10-Q, and 8-K that we filed with the SEC to identify important risks and other factors that may cause our actual results to differ materially from the forward-looking statements. These documents can be found in the Investors section of our website or on the SEC’s website. During this call, we also refer to certain non-GAAP financial measures that include adjustments to GAAP results.

The non-GAAP financial measures presented should not be considered an alternative to the financial measures required by GAAP, should not be considered measures of liquidity, and are unlikely to be comparable to non-GAAP financial measures provided by other companies. Any non-GAAP financial measures referenced on this call are reconciled to the most directly comparable GAAP financial measures in a table available in the press release we issued this morning and in the slide deck available in the Investors section of our website. I will now turn the call over to Tony.

Tony Zook, Chief Executive Officer, NeoGenomics: Thanks, Kendra. Well, good morning, everyone. Thank you for joining us today. As has been our practice, I’ll begin with a discussion of Q4 highlights and key business growth drivers before turning the call over to Jeff for a deep dive into our 2025 financial results. Our new EVP and incoming CFO, Abhishek Jain, will then introduce our 2026 guidance. Afterwards, we’ll open up the call for your questions. Our mission and vision guided us through 2025 to deliver improving results throughout the year. Let’s get into the recent highlights. As we covered in our pre-announcement, during the fourth quarter of 2025, we delivered record revenues while making meaningful progress advancing our NGS and MRD long-term growth initiatives, including preparing for a full clinical launch of our RaDaR ST MRD assay this month. I’ll cover these initiatives in more detail shortly.

Total revenue for Q4 was $190 million, representing double-digit growth of 11% year-over-year. Our clinical business continued its robust growth, with revenue increasing 16% year-over-year. The clinical performance was driven by effective execution of our key commercial strategy, enabling volume and share gains in key segments. In the fourth quarter, we again saw a sequential improvement in AUP, continued growth in test volumes, and NGS revenue growth of 23%, well ahead of NGS market growth rate. The five NGS products launched in 2023 contributed 22% of clinical revenue in the quarter. We continue to see demand for our non-NGS modalities as well, with all modalities continuing to grow at above market rate. Our full, full year total revenue was $727 million, which represents 10% growth over full year 2024.

We ended the year with significant momentum, and I attribute this to several factors. One, we’re a pure-play oncology solutions provider, driving rapid dissemination and adoption of innovation through our best-in-class commercial organization in the community setting. Studies have shown that as much as 80% of all cancer care is now delivered in the community setting, which has historically lagged NCI-designated cancer centers when it comes to introducing the latest in cancer testing innovation. How are we winning in the community? We believe community oncologists are guidelines-driven and focused on certainty, not possibility, and they choose partners that remove friction and enable confident treatment decisions under operational, economic, and time pressures. Reimbursement coverage also is critical. The results of several meetings of our scientific advisory board, as well as independent market research that we commissioned, reveal several reasons why community oncologists look to us.

NeoGenomics offers ease of ordering, simple-to-interpret test reports, fast and consistent test turnaround times, access to medical expertise, and most importantly, our comprehensive test menu spanning diagnosis, therapy, selection, and MRD. Our Net Promoter Score of 79 reflects strong physician satisfaction among our current customer base, with our NPS score continuing to improve in 2025, even with record test volumes. 2, we enjoy a leadership position in the hematology testing market, with greater than 25% share across diagnostics and therapy selections. As pathologists and oncologists consolidate the number of vendors they use, we are successfully leveraging this heme leadership position to create enhanced test demand, particularly in high-value areas such as therapy selection and MRD. In fact, in 2025, we saw 14% growth in the total number of pathologists and oncologists ordering 5 or more tests from Neo.

On top of that, we estimate that approximately 40% of all active pathologists and oncologists have ordered 5 or more tests of ours during the year. While we’re proud of that reach, it also means that over half of practicing providers are still available to us to bring over to Neo. Three, we’ve built a geographically balanced lab network that allows us to be responsive to customer needs, including offering some of the fastest test turnaround times in the industry, when faster, more accurate treatment decisions can have a material impact on patient outcomes. This network was further strengthened by our acquisition of New Jersey-based PathLine last year, which gives us a meaningful presence in the number 3 cancer market in the country. We’re on track to capture operational efficiencies and synergies from the PathLine acquisition that we anticipate will be accretive to profitability beginning this year.

Four, we have one of the broadest cancer test menus in the industry, spanning diagnosis to therapy selection to MRD for both heme and solid tumor cancers, including over 300 commercial payer contracts, which enables us to be the partner of choice among community hospitals and community oncologists. We’re highly differentiated from both large reference labs as well as specialty oncology labs, and this optimally positions us to address under-penetrated markets in therapy selection and MRD in excess of $30 billion, while potentially improving outcomes for patients as they advance along the cancer care journey. We’re enabling precision oncology in the community setting. Turning now to RaDaR ST. In November, we presented new research for the RaDaR ST assay for circulating tumor DNA detection across solid tumor types.

The data from this bridging study showed that RaDaR ST demonstrated 97% concordance and maintained equivalent sensitivity with RaDaR 1.0. This bridging study was used to secure MolDX reimbursement in the two previously approved indications: HPV-negative head and neck cancer, and a subset of breast cancers. This decision paves the way for us to broadly commercialize RaDaR ST, formerly RaDaR 1.1. To that end, we’re on track to execute a full clinical launch of RaDaR ST by the end of this month. As part of our go-to-market strategy, we’re expanding our sales force to help us penetrate the head and neck market. We believe adding feet on the ground will help us penetrate this market with the only MolDX-approved HPV-negative test currently available to patients.

To ensure that we’re well-positioned to capture more of this large and rapidly growing MRD market, we have also submitted 2 additional solid tumor cancer indications for MolDX for approval. While we’re not disclosing these cancer types yet for competitive reasons, we believe that upon securing coverage, we will effectively double the market opportunity of patients eligible for RaDaR ST testing. To expand our reach as we secure additional MolDX approvals, we expect to add more than 25 oncology sales specialists or OSS by the third quarter. From a financial perspective, we believe 2026 will see modest revenue contributions from RaDaR ST as adoption ramps and we gain reimbursement approval in the additional indications. We expect revenue growth to accelerate in 2027 and beyond.

In parallel with our RaDaR ST launch preparedness activities and efforts to gain coverage for additional indications, we also continue to focus our R&D investment in next-generation MRD. This assay will be an ultrasensitive whole genome solution for lower shedding cancer types. We’re working on product development now with data generation and MolDX submissions slated for next year, and a potential clinical launch as early as 2028. Turning now to our PanTracer portfolio of products for solid tumor therapy selection. PanTracer is designed for solid and liquid to work together, empowering oncologists with actionable genomic insights for confident, real-time treatment decisions. The tests can be ordered independently or as complementary tests, depending on a patient’s individual needs.

PanTracer LBx is a non-invasive, blood-based test that analyzes circulating tumor DNA to identify key genomic alterations that inform treatment decisions in patients with advanced stage solid tumors. Importantly, PanTracer LBx fills a gap in our portfolio that providers have been asking for, allowing them to further consolidate the number of labs they use. We have submitted to MolDX for clinical reimbursement coverage of the LBx test and are awaiting a decision. Assuming a favorable decision, we anticipate that LBx will contribute modestly to revenue in 2026 as adoption ramps throughout the year. Another product in the PanTracer family, PanTracer Tissue, had strong growth throughout 2025. We doubled the volume of tests ordered from 2023 to 2024, and then nearly doubled again from 2024 to 2025, while continuing to grow AUPs.

This represents another proof point of our ability to pull higher-value tests through our community channel, leveraging our heme leadership position. 75% of community oncologists who were new to Neo in 2025 ordered 5 or more tests, a strong leading indicator of our continued growth and success penetrating the community channel. I’m pleased to share today that the PanTracer portfolio is growing. Last week, we launched PanTracer Pro as part of the expanded solid tumor therapy selection portfolio. The test integrates broad genomic profiling with diagnosis-directed IHC and ancillary testing, intelligently selected based on tumor type and clinical context, to provide oncologists with actionable insights for therapy selection in a single order. PanTracer Pro rounds out the portfolio, and it will help streamline the ordering and testing process, delivering timely, relevant results, helping clinicians personalize treatment strategies and improve patient outcomes.

At the end of 2024 and moving into 2025, we invested in our commercial organization, specifically our oncology sales specialists. We added 35 people to this group who target community oncologists. As these individuals mature in their roles, we’re seeing a continued uptake in NGS testing, accounting for a larger portion of our total clinical revenue as we increase our reach and frequency. This penetration speaks to the strength of our commercial channel as well. We have launched five NGS products since March of 2023, and even though we were later to market than some of our peers with these products, we are still seeing very good uptake. PanTracer Tissue, highlighted earlier, was one of the five products, which reflects the breadth and strength of our menu and our ability to capture market share when we introduce new products.

With the success of our NGS products, we now have the opportunity to be more selective with the volumes that we prioritize. We are intentionally shifting testing capacity towards more therapy-guided and higher-value testing, which is expected to make AUP expansion a more significant driver of revenue growth relative to volume. With that, I’ll hand it over to Jeff to further discuss our results from the quarter and full year.

Jeff Sherman, Chief Financial Officer, NeoGenomics: Thanks, Tony, and good morning. Fourth quarter total revenue increased by 11% over prior year to $190 million. Total clinical revenue continued with strong double-digit growth and increased 16% from prior year. As expected, non-clinical revenue declined by over 25% in the fourth quarter. Adjusted gross profit improved by $5.8 million, or 7% over prior year, and adjusted EBITDA was $13.4 million, up 10%. Q4 was the 10th consecutive quarter of positive earnings, with adjusted EBITDA and margins improving sequentially each quarter in 2025. Clinical volumes and revenues continued with robust growth in the quarter. Total test volumes increased by 11% in the fourth quarter, with AUP growth of 5%.

Same-store revenue without PathLine was $170 million, representing growth of 14%, driven by a 6% increase in test volumes and a 7% increase in AUP. Volumes were negatively impacted in the fourth quarter as we intentionally rationalized our exposure to higher volume, lower-value test clients. We are continuing to see strength across our portfolio, with above-market growth rates across modalities we offer. NGS revenues grew by 23% over prior year in the quarter and accounted for around a third of total clinical revenue. Average revenue per clinical test increased sequentially from Q3 by $12 or 3% and was up 5% from prior year. Excluding PathLine, AUP increased by $15, or 3% from Q3, and was up 7% over prior year.

A larger percentage of higher-value tests, including NGS, as well as recent managed care pricing increases and RCM initiatives, are helping to drive higher AUP. Total operating expenses in the quarter were $97 million, an increase of $1 million or 1% over prior year. Cash flow from operations was a positive $1 million in the quarter, and we ended the quarter with total cash of $160 million, down slightly from Q3. Our balance sheet and expected cash flow will enable us to continue to invest in our business to drive organic growth through new product development and salesforce expansion, while also increasing operating efficiencies through investments in technology and automation.

Turning to full year 2025 results, revenue is up 10% versus prior year to $727 million, driven by deeper penetration into the community setting, a continuing shift to higher-margin modalities, and execution of revenue cycle management initiatives. Total clinical revenue increased 15%, and growth was 13%, excluding PathLine. Non-clinical revenue declined 24% for the year, in line with our revised expectations. Adjusted gross profit increased $23 million, or 8%, to $335 million. This represents an aggressive adjusted gross margin of 46%, or a decline of 111 basis points, mostly driven by PathLine, the decline in non-clinical revenue, and the operating costs of the clinical liquid biopsy launch. Cash flow from operations was positive $5 million in 2025, with free cash flow improving by over 35% as compared to 2024.

Adjusted EBITDA increased by $4 million to $43.4 million, an improvement of 9% over prior year. Now I’ll hand it over to Abhishek to introduce our 2026 guidance.

Abhishek Jain, EVP of Finance/Incoming CFO, NeoGenomics: Thank you, Jeff. I would like to begin by thanking my colleagues at Neo for their warm welcome. Over the past month, I spent time with investors and analysts, attended our global sales meeting, visited our labs, and gained deeper insights into our strategy and the opportunities ahead. It has been a productive and energizing first month. With that context, let me share our 2026 guidance. For the full year, we expect revenues of $793 million-$801 million. The midpoint of our 2026 revenue guidance assumes RaDaR ST revenue in mid-single-digit millions for our approved indications. A modest revenue contribution from PanTracer Liquid and sustained softness in non-clinical through the year, exiting 2026 down low- to mid-single digits.

While we do not provide quarterly guidance, let me provide some color on quarterly cadence that is impacted by the PathLine acquisition and revenue assumptions for RaDaR ST and PanTracer Liquid, which are weighted towards the back half of the year. I suggest modeling approximately 10% year-over-year growth in the first quarter, 8%-9% in the second, 9%-10% in the third, and slightly above 10% in the fourth quarter of 2026. Regarding the extreme weather throughout the country so far this year, we know some providers had to close their offices and appointments have been rescheduled.

Warren, Sales Leadership, NeoGenomics: ...As a result, there will be some impact on volumes and revenue for Q1. This has been contemplated in our full year 2026 guide and cadence by quarter. We expect adjusted EBITDA to be in the range of $55 million-$57 million for 2026, representing year-over-year growth of approximately 27%-31%. We expect adjusted EBITDA to grow by low 20s% year over year in the first and the second quarter, and low 30s% year over year in the third and the fourth quarter, respectively. We will continue to take a balanced approach to investments, strategically increasing sales and marketing and R&D spend for new product initiatives and clinical programs that support payer reimbursement and drive top line growth, while improving liquidity with the goal of becoming free cash flow positive this year. Now, let me turn the call back to Tony.

Tony Zook, Chief Executive Officer, NeoGenomics: Thanks, Abhishek, and welcome to the team. To recap, during the fourth quarter, we again delivered very strong clinical volumes and revenue while advancing NGS and MRD initiatives that we believe will contribute to accelerating our growth for years to come. Looking forward to 2026, in our clinical business, the focus is on strategic, profitable growth, driven by continued expansion of NGS revenues and market penetration for the PanTracer family and RaDaR ST. Simultaneously, we’re implementing tools and solutions we believe will enhance the productivity of the entire sales organization and working to enhance customer workflows through solutions like our Epic Aura integrations. In parallel with our product and service offerings to grow revenue, we are making targeted investments to drive top-line growth and margin expansion.

There is a very strong financial discipline embedded throughout the organization, and we’re going to build on that as we continue to grow revenue and improve operating efficiencies and margins. Thank you for your continued interest in NeoGenomics. Operator, this concludes our prepared remarks, so please open the line for questions.

Kelly, Conference Call Operator: Certainly. The floor is now open for questions. If you have any questions or comments, please press star one on your phone at this time. We ask that while posing your question, you please pick up your handset if listening on a speakerphone to provide optimum sound quality. Please hold just a few moments while we poll for questions. Your first question is coming from David Westenberg with Piper Sandler. Please pose your question. Your line is live.

Speaker 5: Hi, thank you so much, and good morning. So I’ll just ask one question, but it will be, you know, kind of on the longer side. I’ll just ask it up front. You talked about the initial launch of RaDaR ST. Can you provide a little bit more specifics? You mentioned specific submissions to MolDX. Can you give us more specific timing? I get that, you know, this is trying to predict government, but, you know, is this end of the year? Is this, you know, potentially dragged into the next year, et cetera? And then you mentioned also 25 sales reps. I just want a clarification that is specific to MRD or esoteric tests in general.

And then, on those sales reps, do you plan on just going after the head and neck, the sub-indications of breast, or are you actually, in fact, thinking about, some of those future MolDX submissions that you have there? And then lastly, I get this is really long, but, you know, just talk about the complementarity with PanTracer liquid. Thanks so much.

Tony Zook, Chief Executive Officer, NeoGenomics: Okay, so Dave, there, there’s a lot to unpack there. Why don’t I, I’ll try and start it and kick us off and then look to Warren to address perhaps follow-up questions six, seven, and eight. Okay, Warren, so get ready for that. Relative to RaDaR ST, Dave, you are right that the intention is we go out, at the end of this month for our full launch. Relative to focus, it will be focused, Dave, on the initial indications of head and neck and the subsets of breast that we have articulated, HPV-negative and the HER2-negative breast. So that was one of your questions.

As far as additional indication flow, as you say, you know, all we can do is submit, and put the best packages forward that we believe are possible for MolDX to work their way through. For our own assumptions, we believe, Dave, that those additional indications would be available in the latter half of this year for us, and so, still possible to potentially generate some revenue from those in this year, but that would be upside against our guide, Dave. We’re not counting on those and certainly will help fuel additional robust growth going into 2027. Relative to the actual field force expansion, I’m going to turn that over to Warren, because what we wanted to do, Dave, was do two things.

First and foremost, we wanted to take advantage of the HPV negative indication because we believe we’ll be the only MolDX approved product for HPV negative. And it’s a very specialized group of physicians that account for that bulk of that business, and there’s a fairly clear roadmap to how we can get to those. And so Warren’s team is initially now expanding to cover that group, and then he will build the additional reps over time for the added indications that we have. And yes, Dave, they are intended to be complementary to MRD and NGS. They won’t be specific only to MRD. So Warren, maybe a little bit more color on the coverage aspect.

Warren, Sales Leadership, NeoGenomics: Absolutely. Thanks, Tony, and morning, Dave. So yeah, the expansion is taking place. There’s an initial expansion happening sort of as we speak. That is to really address the RaDaR ST launch, and particularly head and neck HPV-negative. And the reason why we felt we needed to do a small initial expansion is, one of the primary call points for head and neck HPV-negative is the ENT, and that hasn’t been a traditional call point for us up until now. So, we’re actually investing in a small team dedicated towards ENTs, and they will be almost exclusively focused on the RaDaR head and neck indication. They will have an option to represent other parts of the portfolio, but we feel that their focus will be largely focused on the RaDaR ST.

As we’ve done in the past, and very successfully, I might add, as we expect new products, and in this case, new indications to come to market, we do expand our sales force because we want to increase reach and frequency. We will be doing that in quarter two and in quarter three, in anticipation of the additional indications that we expect from MolDX. Again, these team members will be oncology sales specialists. They will be responsible for selling our oncology portfolio, which is therapy selection for heme and solid tumor, as well as MRD. It’s probably a bundle of about 12 or 14 tests if you really look at it. But we see a 100% core point overlap between our portfolio for therapy selection as well as MRD.

Today, based on the size of our sales team, we feel we get more value by consolidating sales activities within one resource versus having specialized sales teams. Although we will get some good lessons from our dedicated ENT group that we’re establishing as we speak.

Tony Zook, Chief Executive Officer, NeoGenomics: Thanks, Dave.

Speaker 5: All right. Thank you, guys.

Kelly, Conference Call Operator: Your next question is coming from Bill Bonello with Craig-Hallum. Please pose your question. Your line is live.

Speaker 3: Hey, guys. Hoping to sneak in a couple, but the first would be just on the clinical volume. Is any chance you could quantify the impact of exiting the low-value business, and then maybe clarify whether there’s you know, more business that you will still be exiting in future quarters so we can have some sense of how to think about volume growth, as we progress-

Tony Zook, Chief Executive Officer, NeoGenomics: Mm-hmm

Speaker 3: ... through the year?

Tony Zook, Chief Executive Officer, NeoGenomics: Sure, Bill. I’ll kick that off. And again, I’ll look to Abhishek or Jeff to add in any additional color. So Bill, if you just step back and you look at us historically, right? If you looked at how the revenue models were built, you know, volume represented for us, typically, you know, this upper to single digits growth, and AUP was more in the low single-digit growth. There’s two factors that are driving our thinking now. First of those is this constant and purposeful penetration into therapy selection and MRD. With that, we will be the beneficiaries of higher AUPs and therefore a better impact on our margins and business overall. So that’s point number one. We expect our AUPs to continue to grow.

And then the second point, Bill, was this idea: we wanna make sure we secure the right vol. We wanna be a business that’s growing our revenue as well as our margins over time. And you’ll recall that we had, we talked about a contract throughout last year that was a high volume, low value-added opportunity for us. The AUPs, Bill, in that were, like, in the low $200 range. We entered into that with the potential opportunity to secure longer-term growth into higher value tests. But if they don’t materialize, we had to look at it in a macro sense, and for us, we believe the better course of judgment here was to say, our resources are better used and focused in the areas where we’re seeing higher margin opportunities and higher growth. And so the model now kind of inverts a little bit.

What you should be expecting is AUP now in the upper single-digit range, with volume in the lower- to mid-single-digit range. But that being said, I just wanna make sure we clarify this, Bill, because it’s an important point. We’re still growing all the right volumes, right? We’re gonna continue to grow by modality. We have no desire to pull back in that area. We continue to expect NGS to have robust growth as well. And so that’s going to continue. We saw robust NGS volume and AUP growth in 2025. We would expect similar results in 2026, and so the right volume will come through. And on that NGS business, again, you know, it’s now over a third of our clinical business.

And an interesting fact, Bill, is that, you know, that third of our clinical revenue, it’s actually being supported with only 9%-10% of our volume. And so it’s the right volume that’s generating these kinds of growth numbers. So, I would expect most of this to be evident through Q1 and Q2, and then from that point on, we’ll be back to kind of normal growth trends. Does that help, Bill?

Speaker 3: It does. And, I mean, should we think even a bit lower, perhaps, as we get into Q2 and Q3, just then on the volume growth? It sounds like maybe a little to still come, or is this a pretty good proxy?

Warren, Sales Leadership, NeoGenomics: So let me take that one, Bill. So we are, like, for example, what we have seen in Q4 results, our sequential volume growth was slightly down, and we are anticipating as we kind of go in Q1, our numbers will be sequentially down in similar vein as we kind of start to focus on these high-margin, high-value tests. And this is very intentional from a strategy standpoint, and that’s the reason we are moving in that direction. But as we get into Q2, we’ll basically be year-over-year flattish, and that’s where we will start to grow our volumes in Q3 and Q4 on a year-over-year as well as on the sequential basis.

Speaker 3: Okay, that’s really helpful. Thank you.

Tony Zook, Chief Executive Officer, NeoGenomics: Thanks, Bill.

Kelly, Conference Call Operator: Your next question is coming from Andrew Brackman with William Blair. Please pose your question. Your line is live.

Speaker 1: Hi, guys. Good morning. Thanks for taking the questions. Maybe just also a similar line of questioning to Bill here, just sort of around guidance. Just by my math, it looks like the core clinical business, when I exclude PathLine and some of these new contributions from LBX and MRD, it looks like that core is called to sort of grow in that high single digit to maybe 10% year-over-year. Can you maybe just unpack some of the underlying assumptions there for that core book of business? And I guess, in particular, just sort of reconciling that to the, I think you did 14% same-store sales growth in Q4. So just sort of reconciling that to that high single to 10% growth. Thanks.

Tony Zook, Chief Executive Officer, NeoGenomics: Yeah, Andrew, again, I’ll kick it off, and I’ll look to Abhishek and Jeff to add additional color. So, yes, in 2025, you saw, you know, ex-PathLine, we were about 13% growth on the clinical side. And, you know, we are anticipating, you know, double-digit growth on the clinical, and so what’s within there? First, there will be the full year of PathLine that will be built into the numbers as well. As I just mentioned with Bill, that one contract that we exited, that has an impact in the totality of the clinical side. And then, of course, in the guide itself, Andrew, just to be clear, we wanted to be prudent relative to the back half with LBX.

Since we still do not have LBx approval in hand, we thought it better to only pack in revenue for the second half of the year at a modest rate. So we don’t really see the benefits of that coming through in the current guide. If we, in fact, get LDT support for LBx earlier than that, then it would represent upside in our total growth, and of course, that would be on the backs of the total clinical business. So again, I hope that gives you some color, and Abhishek, if I missed any key points, please call out for Andrew.

Abhishek Jain, EVP of Finance/Incoming CFO, NeoGenomics: No, I think you have covered it well, Tony. And Andrew, we are expecting the clinical business to be growing at about 11% based on our low- to mid-single-digit on the non-clinical side. So it’s kind of in the range that we have been expecting the company to be growing in, like, at about 10%. That’s what we have called out, and that’s where our midpoint currently is, $797 million. It’s pretty close to that 10%. I think the guide is pretty prudent to the extent that it gives us a very high degree of confidence to be able to meet these numbers. And then we will, of course, see if the things were to pan out as we are anticipating, it gives us some room to actually do better than the expectations.

Tony Zook, Chief Executive Officer, NeoGenomics: Does that help, Andrew?

Speaker 1: That’s helpful. And then... Yeah, that’s very, very helpful. Thanks for, thanks for all that color. And then just, just on the LIMS rollout here, you know, obviously, that’s a, that’s a multi-year process for, for that rollout, but anything you can maybe share with respect to how that might be impacting the model or sort of just sort of, sort of the workflow in 2026? Thanks.

Tony Zook, Chief Executive Officer, NeoGenomics: Yeah. Yeah, great question. Thank you for that. As you know, historically, we were built for effectiveness, not necessarily for efficiency. And moving to a common LIMS system, we think is foundational for us to continue to advance towards ever-improving margins and efficiencies for the company. What we will see through the course of 2026, Andrew, you know, we have these eight existing LIMS systems, we’ll be on a path to migrating to one common system. What we want to do, though, is manage that effectively over time. And so we are going modality by modality, site by site. We’re not going to just do kind of a big bang theory and put any risk at all into the business.

And so that means the benefits of LIMS only start to become evident for us, in the latter part of this year. Now, there are some natural efficiencies that Warren’s team are already seeing, and I’ll look to him to add some of that added color for you. But the more pronounced impact will be in 2027 and 2028, as we can retire all the legacy systems and build upon, the existing LIMS architecture. So, Warren, any added color?

Warren, Sales Leadership, NeoGenomics: Yeah. Thanks, Tony. Andrew, I think, yeah, in terms of sort of technical debt benefit, that’s coming in 2027, to be clear. But, you know, as we put the LIMS system in now, we’re actually not just replacing our existing 8 LIMS with the new LIMS. We’re actually looking at the workflows and optimizing the workflows based on how we understand the business and how it’s likely to develop over time. So as we get each modality in place or in each site, we start to see workflow efficiency there. So that’s sort of, well, something that will start to come through in operational efficiency. I think the other big benefit that we’re getting is far greater capabilities from an analytics and insight point of view to really understand where inefficiencies lie within our workflows.

That analytics and sort of transparency will also help us translate a better customer experience by providing visibility to real-time sample tracking, et cetera, which is one of our key initiatives for 2026.

Tony Zook, Chief Executive Officer, NeoGenomics: I would say, Andrew, again, this is foundational for us because it affords us then the opportunity to build on that, which is why I maintained that we’re still in the early innings relative to gross margin expansion opportunities for ourselves. You know, we throw in LIMS, and then you look at other platform opportunities like, you know, DX and things that Warren and his team can do with digital pathology and automation. We believe that the gross margins are in early, and we can continue to build not just revenue, but margin expansion as well.

Speaker 1: Okay, appreciate all the color. Thanks, guys.

Tony Zook, Chief Executive Officer, NeoGenomics: Thank you.

Warren, Sales Leadership, NeoGenomics: Okay.

Kelly, Conference Call Operator: Your next question is coming from Subbu Nambi with Guggenheim. Please pose your question. Your line is live.

Speaker 13: Hey, guys. Thank you for all the color in different businesses. Given some longer selling cycles and maybe some easing of the funding pressure, where do you see pharma ordering playing out this year between the first half and second half? And what products do you expect to lead the order book from pharma?

Tony Zook, Chief Executive Officer, NeoGenomics: Could you repeat the second half of the question, please?

Speaker 13: What products do you expect to lead the order book for pharma?

Tony Zook, Chief Executive Officer, NeoGenomics: ... Okay, got it. So relative to pharma, I would say that my views certainly have not changed from where we were about 6-8 months ago. We, we anticipated, you know, that this erosion that we were experiencing on the pharma side of the business, would continue into 2026, albeit not at the same rate that we saw in 2025. So I have always been of the belief that it would be 2027 before we would see a return to growth for that book of business. And that’s how we built the guide. So we expect still to see modest erosion in the pharma book of business for 2026.

Certainly, it’ll be much reduced from where it was, but still in that, you know, mid to upper, you know, 5%-10% range for the pharma side of business. I think the big part of the return to growth there is based on RaDaR ST. That will be one of the key growth drivers for us in that book of business. You know, we’ve had pretty good conversations. We’ve been well-received. You know, we’re back at the table with RaDaR ST. There seems to be a really good sense of interest in it, and that portfolio of opportunities continues to grow. And so relative to the year, again, the guide would still anticipate a modest erosion in the pharma side of the business.

If we can get that back flat, that would then represent upside opportunity for us. Warren, I know the long lead cycle times, but perhaps you could talk about RaDaR ST and how that’s being received.

Warren, Sales Leadership, NeoGenomics: Yeah, Tony, maybe a couple of comments there, Subbu. So first and foremost, in terms of the focus, you know, a little bit like on the clinical side, really, our focus is to protect our position in diagnosis, but really look to grow in therapy selection and MRD. We look at pharma in a very similar way. You know, we are... We’re very well known from an IHC perspective, and we continue to focus on IHC because it’s very relevant for pharma from an antibody drug conjugate perspective, and it’s a good door opener for us. But expect our focus to really lie towards therapy selection and MRD. So there’s a strong alignment here between what we’re doing in clinical and with pharma.

As Tony said, robust opportunity pipeline that’s developing with regards to RaDaR ST and pharma, some legacy users and many new users, and expect first bookings to materialize, shortly.

Tony Zook, Chief Executive Officer, NeoGenomics: And I do appreciate the question. You know, this gives us the opportunity to clarify it. The other thing I just would remind the group, this is a relatively small portion of our overall business. We’re talking, it’s about 5%-6% of our overall business. And so we continue to put the primary focus and energies on the clinical side of the business, with the intent to stabilize this business and return to growth in 2027. So thanks for the question.

Speaker 13: Absolutely. Thank you for clarifying this. Can you talk about the framework for LIMS integration this year? What’s being finished, what’s left to go, and then maybe how that will show up in earnings in 2026?

Warren, Sales Leadership, NeoGenomics: I’d say where our focus is today, so it. We’ve completed flow, so one of our key modalities. Our next step right now is around accessioning and NGS, is really where our focus is. Again, aligning to our strategic priority, looking to be able to provide increased value, both from an efficiency perspective and customer traceability. Those would certainly be things that you would look to conclude in 2026. Probably for other modalities as well, rolling into that, but we can certainly take that offline and provide more granular detail if you like. But those are the key focus areas for us in 2026, is molecular and accessioning.

Tony Zook, Chief Executive Officer, NeoGenomics: Great. Thank you.

Speaker 13: Okay, thank you so much, guys.

Kelly, Conference Call Operator: Your next question is coming from Mike Matson with Needham. Please pose your question. Your line is live.

Speaker 7: Hi. Thanks, everybody, for taking our questions. This is Joseph on for Mike. Just, I guess, in terms of the guide for RaDaR for 2026 in the mid-single-digit millions, I’m just kind of wondering, framing up your guys’ confidence in the ability to hit that mid-single-digit number. And I guess just trying to understand, how much of that is, is the clinical side versus the, the biopharma side? You know, maybe for both of those, you know, which do you see to have the, the, the higher potential to drive upside to that, to that mid-single-digit number?

Tony Zook, Chief Executive Officer, NeoGenomics: Yeah. Thanks for the question, Mike. I would say, first and foremost, we do have a high degree of confidence in that. That’s why it’s in the guide at the midpoint level. So we do have a high degree of confidence there. Relative to the mix, yeah, I think it would be fair to say in the early part of the launch, you would expect a heavier component of that to probably be more on the pharma side than the clinical side. Only because the clinical launch just takes time to build, right? You know, we’ll have the indications of head and neck and breast, and then you’ll build, and you’ll start to see a slow build of that activity.

And just with the lead times of the product, you know, you start to see the clinical effect of that probably in the latter part of the year. Whereas pharma, you know, you have the opportunity to take on a little bit more of a pan orientation and can secure pricing sooner. And then as we build the indications, over time, you’re going to see the clinical side of the business certainly accelerate, and that would be the largest of the drivers moving into the outer years with RaDaR ST. Abhishek, anything else of-

Abhishek Jain, EVP of Finance/Incoming CFO, NeoGenomics: No, I think, Tony, you have covered it very well. As I basically discussed in our prepared remarks, we are actually launching, RaDaR ST by the end of this month, and that gives us very high degree of confidence of the numbers that we are putting in, in our guide.

Tony Zook, Chief Executive Officer, NeoGenomics: Thank you.

Speaker 7: Okay. Yeah, great. And then maybe just one more quick one. Can you maybe just talk about the, you know, the potential for continued ASP growth? You know, I think you guys were kind of talking about high single digits, or, you know, upper single digits, maybe for 2026. But, you know, the potential for that to continue without any additional reimbursement announcements. So, you know, what is currently approved and reimbursed in your pipeline, you know, NGS products, PanTracer, as it stands today without LBx?

Tony Zook, Chief Executive Officer, NeoGenomics: Yeah, I’ll start, and Abhishek can join this, Jeff. So I think, look, the continued shift into NGS is gonna be continue to be the big driver of our AUP growth, as it was in 2025 as well. So I think that is one factor. We expect to continue to have success with direct client bill pricing increases, which generally going in the first quarter of the year. And we also are continuing to have success with managed care pricing increases, which started in the back half of last year. We’re expecting full year impact of those to hit in 2026, as well as new agreements or new increases approved. And then finally, we’re still working on other RCM initiatives to kind of close that gap between what we expect to be paid and what we are being paid.

So, you know, that AUP growth will come for those drivers to the extent we get additional, you know, indications or tests approved, that will be incremental on top of that growth.

Speaker 7: Thank you.

Kelly, Conference Call Operator: Your next question is coming from Tycho Peterson with Jefferies. Please pose your question. Your line is live.

Speaker 15: Hey, thanks. Maybe one for Warren. Just on the sales force, I appreciate your, you know, color on go-forward additions. But as we look back, you know, over the last year, obviously, you know, ramping the sales force was a big focus. Maybe with that cohort matured, can you just talk about, you know, where they are in terms of productivity? I think, you know, you called out over five tests ordered, you know, on providers.

Tony Zook, Chief Executive Officer, NeoGenomics: Mm-hmm.

Speaker 15: But maybe just any other metrics we can, you know, look to track, you know, the scaling up of the sales force over the last year. And then separately-

Tony Zook, Chief Executive Officer, NeoGenomics: Yes.

Speaker 15: Are you baking anything in for, you know, Adaptive related revenues this year and any metrics, you know, you can provide there?

Warren, Sales Leadership, NeoGenomics: Thanks, Tycho. Yeah, absolutely. As you pointed out, we did expand our sales force late 2024 and into the beginning of 2025. We kind of see that sort of 6- to 9-month ramp-up period, and I would say that that sort of maturing or that productivity of those resources was a big contributor to our success in H2 of 2025. And we anticipate that that’s going to be a tailwind for us in the first half of the year, for sure, as that sort of momentum continues to annualize into this year. Again, the focus of those resources, they’re oncology sales specialists, so they’re really focusing in on therapy selection, and they’re gonna be supporting our launch from a RaDaR ST perspective in MRD. So that’s where the focus is.

I would say that those resources are at productivity now, so sort of in stride. The positive is we’ve seen very, very low attrition as well, so it’s not like there’s been a high churn or anything. So I feel we’re executing well, and we’re starting to see general increased productivity across our entire sales team, not just the 35 that we brought on board in 2025. The sort of entire 140 or so that we have within our complement today.

Tony Zook, Chief Executive Officer, NeoGenomics: Tycho, the only other few points, I’ll do a little bragging for Warren and his team, he may be a little humble here. I think if you look to how that expansion has taken place, there are some proof points that we could look to. I mean, first and foremost, you do got to look at that NPS score, right? You know, to have an NPS score of 79, it, which is a step up from where it was already, and that’s heavily based now with feedback from oncologists. So I think that is a really positive sign that the reach and frequency model is beginning to have an effect.

And then within the subsegments of our own data, when you start to see 14% of oncologists and pathologists are now ordering 5 or more Neo tests, I mean, I think that’s another proof point that this model is taking effect, and we have now over 40%, we estimate, of oncologists, pathologists prescribing 5 or more tests. I think these, these things are what’s fueling the NGS growth opportunities for us, and I think to take this sales force on that journey over the past, you know, 12-16 months has been an incredible one, and one we’re proud of and one we’re gonna continue to build on. And then relative to your second question, I, I would say that from a, a revenue perspective, we look at the Adaptive partnership much, probably more strategically than economically.

You know, we see it as an offering that we can offer our, our customers, that offers them then an expansive portfolio of opportunities for us. Over time, we will see... We’ll be a company that can offer flow MRD, we can offer heme MRD, we’ll have RaDaR ST, we’ll have next gen MRD. And so that, that whole suite of products we think is an important one to offer and to have an outstanding partner like Adaptive, is, is more strategic than I would say it’s economic, at least, for us. But we’re gonna continue to, to work and, and manage that relationship to the best of our ability. Thanks for the questions.

Speaker 15: Thank you.

Kelly, Conference Call Operator: Your next question is coming from Dan Brennan with TD Cowen. Please pose your question. Your line is live.

Speaker 4: Great, thank you. Maybe just to start off, just on PanTracer, I understand the conservatism there. Just any more color about kind of the back and forth, it sounds like it’s imminent. But the blood market is growing a lot faster than the tissue CGP market, so you’ve had really good success on tissue volumes. Just, you know, is, is it just conservatism, or like, what do you expect, you know, once that’s really dialed in for that PanTracer liquid to grow at from a volume basis?

Tony Zook, Chief Executive Officer, NeoGenomics: Yeah, I’ll kick us off, and then Abhishek and Warren could add a little bit more. So yeah, Dan, we have responded to all the questions that MolDX had relative to LBx, and so we’re just, you know, kind of in a waiting a response mode. Now what we have seen is across, it’s not just us, but across the sector, it’s been averaging about 4-5 turns through MolDX for new offerings. And so that puts us right around, you know, 4 turns is right around the 12-month mark, and so that’s kind of where we sit today. You know, so we are confident. We see this as a when we get it, not an if we get it.

And then we—that’s why we thought, yes, it was prudent to not include revenue for the first half of the year, and then just kind of a modest and slow build in the second half of the year. And anything that would come before that would then be opportunistic upside for us. Relative to kind of modeling at the high level, you know, again, you, you called it out. PanTracer Tissue is enjoying robust growth. We highlighted before the volumes from 2023 to 2024 doubled. We saw the same, almost nearly doubling in 2024 to 2025. We think that’s probably a decent predicate as a way to look at LBx over time.

And so we look to our total NGS portfolio, of which the PanTracer family is a big driver of that, you know, to experience a robust growth again in 2026 and beyond. It’s certainly in line with 2025, and then depending on MolDX timing, it could be better than 2025. So hopefully that gives you a little bit more color, and Warren, I don’t know if you want to get any more specific about how you’re seeing with LBx and tissue.

Warren, Sales Leadership, NeoGenomics: Yeah, I’d, I’d say the following. I think, Dan, you’re, you’re right that the liquid market is growing faster. Since the launch of PanTracer liquid, we’ve actually seen a good acceleration across the category. We saw increase in utilization of PanTracer Tissue, and we’ve seen attractive uptake of PanTracer liquid as well. And we feel... And actually, we launched PanTracer Pro very late last week and expect that to be another inflection point in terms of how this solution for solid tumor therapy selection is positioned for the market. So we’re. I’m very confident in terms of the outlook here. It’s really just around unknowns with regards to MolDX reimbursement timing, I think is what you’re seeing within the thought process from a guy’s point of view.

Jeff Sherman, Chief Financial Officer, NeoGenomics: Yeah, we launched PanTracer Tissue in end of Q1 in 2023, and, you know, it started to build throughout 2023, and then we really saw a big uptake in the first and second quarter of 2024. And that was a big driver of our NGS growth during that time. Thanks, Dan.

Tony Zook, Chief Executive Officer, NeoGenomics: Great.

Kelly, Conference Call Operator: Your next question is coming from Puneet Sudha with Leerink. Please pose your question. Your line is live.

Speaker 12: Yeah. Hi, guys. Thanks for the questions here. So, just clarifying, given the guide here, is the long-term, LRP that you had put out earlier, I believe 12%-13%, is that, still, in consideration, or is that off the table? And then, if I look at the same store sales, versus, new tests, 5% revenue per test growth reported versus 7% same-store sales, can you elaborate on, you know, how do you expect to convert these new customers to sort of higher value tests, and how long would that take, for us to, you know, start to see an impact there? Thank you.

Tony Zook, Chief Executive Officer, NeoGenomics: Okay, so Puneet, first on the first question, you know, we are, we’re not talking LRP. You know, we’ve tried to make it clear as we can that, you know, we’re taking our feet and firmly planting them in the year we are in. And so I’m not projecting it out. I would simply say that, I believe that we will... This guide, we are very confident in. I think we will end the year, in a, in a very strong position with accelerated growth opportunities as we head into 2027, and we would start to then see the full benefit of RaDaR ST and, PanTracer LBx coming through the system. So I-- but I won’t go into any more relative to, an LRP discussion. The second question?

Jeff Sherman, Chief Financial Officer, NeoGenomics: Yeah. From an AUP perspective, you know, with the guide going on, I think adding those tests and coming in the back half of the year, you should expect AUP will grow as we add those incremental tests over time. And I think that’s... 25 was kind of a good example of that.

Abhishek Jain, EVP of Finance/Incoming CFO, NeoGenomics: Yeah. No, but my sense is also that AUP, as we kind of move into these high-value tests, right? Because, in any case, these are going to be priced at a much better rate, and we expect the AUP will grow as we move in this direction.

Jeff Sherman, Chief Financial Officer, NeoGenomics: Yeah. And as you said, you know, Pete, so the same store, excluding PathLine was higher, it was in the mid-single digit in the quarter. And I think over time, adding these tests in the back half of 2026 will help drive AUP growth as well.

Warren, Sales Leadership, NeoGenomics: So, Puneet, maybe building on this sort of opportunity to penetrate and how long... You know, again, coming back to that commercial strategy to protect, expand, acquire, done a really good job of protecting that sort of hole in the bucket is really something that has improved significantly, and the NPS score sort of helps to drive that. But the expand element of the strategy is very much around taking new products and selling them to existing customers. That’s an active part of the strategy, and we do that both on the pathology side of the business for the TBMs, where relevant, but very specifically on the oncology side as well, with the oncology sales specialists.

You know, as we bring on more and more new oncology practices, you know, we typically lead in with a heme solution because that’s where we differentiated, and then we use that as a basis to expand into solid tumor. Yeah, it’s difficult to give you a finite example of exactly how long it takes because every practice is different. But sales cycles here are relatively quick, and as soon as we can put sort of interfaces in place to streamline workflows, introduce things like PanTracer Pro, we expect that acceleration to or the speed to accelerate through 2026 and into 2027 as well. So the active part of the strategy, I’m very confident in our ability to pull that through based on past experiences.

Speaker 12: ... And on that, thanks. And just very quickly on the leading with heme and then entering with solid tumor into those accounts, could you just elaborate on, you know, sort of what you see as the competitive landscape in, you know, in tissue CGP today and also liquid? Obviously, you know, significant penetration in the market, multiple competitors out there. Maybe just give a sense of how you think you’re positioned today in the community setting versus the competition that you’re seeing in the community setting. Thank you.

Warren, Sales Leadership, NeoGenomics: Vini, I’d say that we haven’t seen a marked change in terms of what’s happening from a landscape perspective on the solid tumor side of things in the community setting where we are focused. As we’ve said before, we tend to bump into most of the normal competitors in different parts of the country, et cetera. We find our portfolio to be very well received based on the fact that we focused on actionability and a high degree of service. And you know, a stat that Tony shared earlier, that 75% or 3 out of 4 new oncologists that try us tend to stay with us. And that’s not only unique in the heme side of things, that happens through on the solid tumor side of things as well.

So, certainly, it is a competitive landscape, but I can’t say I’ve seen any material changes. And we’re seeing success on the liquid side of things as well, despite the fact that we’re a late entrant. And I put that down to the fact that we have a broad portfolio, and physician practices are looking to simplify their workflows and standardize on vendors, and that places NeoGenomics in a very favorable position. Thank you.

Speaker 12: Great. Thank you.

Kelly, Conference Call Operator: Your next question is coming from Mason Carrico with Stevens Inc. Please pose your question. Your line is live.

Speaker 10: Hey, guys. On MRD, for the two indications that you submitted, do you plan on launching RaDaR for those indications ahead of MolDX approval to start building that volume stream, or do you plan on launching after you gain coverage?

Abhishek Jain, EVP of Finance/Incoming CFO, NeoGenomics: Yeah, as I tried to convey earlier, we’re going to stay focused on the two initial indications of head and neck and the subsets of breast in the initial launch period. And then we will expand accordingly as we get MolDX coming through the system. You know, there certainly would be enough on our plate in the short term with just those two, and then we’ll build in the latter half of the year.

Speaker 10: Got it. And then on the 23% NGS growth in the quarter, could you provide any additional detail, I guess, on how much of that maybe came from the core existing business versus pull-through tied to the PathLine acquisition?

Speaker 12: The bulk of it would still be the existing-

Abhishek Jain, EVP of Finance/Incoming CFO, NeoGenomics: Yeah

Speaker 12: - business, with PathLine starting to ramp, is how I would characterize it.

Warren, Sales Leadership, NeoGenomics: We’re certainly seeing increased activity and penetration in the Northeast, but just, yeah, the center of gravity lies towards the other business, so therefore, that’s where the lion’s share is still coming from.

Speaker 10: Got it. Okay, thanks.

Kelly, Conference Call Operator: Your next question is coming from Mark Massaro with BTIG. Please pose your question. Your line is live.

Speaker 9: Hey, guys. Thanks for taking the questions. I’ll keep it to one. Can you just speak about how we should think about gross margins in 2026? 2025 was obviously down. When we put sort of the different, you know, increase in next gen, I could see how there could be a path to gross margins increasing in 2026, but however, there are some other headwinds as well. So can you just give us a sense if you think gross margins can grow this year and any ability to quantify that would be helpful.

Abhishek Jain, EVP of Finance/Incoming CFO, NeoGenomics: Sure. Absolutely, Mark. Let me take this question. So most of our adjusted EBITDA margin expansion in the current year, in 2026, is going to be coming from the growth margin. So we are anticipating the growth margins to expand at about 100 basis points, and that’s gonna basically drop to the adjusted EBITDA margin expansion as well. And there are multiple reasons, of course, on the growth margin expansion as we kind of look at our pricing increases, as well as we rationalize our portfolio to the higher value, higher margin products, as well as the work that our labs are doing to be more efficient there.

The growth margin is expected to improve at about 100-120 basis points in 2026, and most of that is going to be dropping to our bottom line on the adjusted EBITDA.

Speaker 9: Great. Thank you.

Speaker 12: Thanks, Mark.

Kelly, Conference Call Operator: Your next question is coming from Andrew Cooper with Raymond James. Please pose your question. Your line is live.

Warren, Sales Leadership, NeoGenomics: Hey, everybody. Thanks for the question. Maybe first, Tony, I think you said you expected NGS growth to look pretty similar in 2026 to 2025. I know the target’s 25%. You know, you were, you were almost there, but not quite. You have some of these tailwinds when we think about PanTracer liquid coming on, at least in the back half. I don’t know if you’ll count MRD in, in kind of that bucket with NGS when you think about the target, but how do we think about that trending through the year, especially in context of a sales force that’ll be essentially tripled or quadrupled by the time you’re done adding?

Abhishek Jain, EVP of Finance/Incoming CFO, NeoGenomics: Yeah, I think, as you rightly put it out, we showed about 23% for the quarter, about 22% year over year for NGS growth. I would expect that we should be able to do that in 2026. If not, we end up slightly better than that. And that’s gonna be driven, as you say, by the momentum of the sales force that we have, the addition of LDX into the portfolio, PanTracer Pro. So we expect that we should do at least as well as we did in 2025, with the opportunity to maybe even beat that slightly, and much of that will be dependent on the timing of LDX. And so I think that’s a safe assumption to take into the year.

Speaker 2: ... Okay, that’s helpful. And then maybe just lastly, for Jeff or Abhishek or Tony, if you want to chime in as well. But, you know, when we think about that shift of growth being heavier volume versus AST to the other way around and more AST or AUP driving that growth, how does that change the way you think about that margin drop through over the longer term? It sounds like, you know, when we think about 2026, there’s certainly some reinvestment that’s probably eating up a bit of the flow through that would be there otherwise. But, how does that change the way you think about sort of the long-term trajectory from a margin perspective, if at all?

Tony Zook, Chief Executive Officer, NeoGenomics: Yeah, great question.

Abhishek Jain, EVP of Finance/Incoming CFO, NeoGenomics: No, that’s a great question, Andrew. And, that’s, that’s I think the key strategic question that we have, with Neo, that we have a broad range of portfolio here. We have tests that are like $100, $200 AUP, and then we have very high-value tests on the NGS side. Now, that also basically kind of differentiates us from some of the other specialty diagnostic labs as to how we are thinking about our volumes. Now, when we look at our capacity, when we are, when we’re looking at our portfolio, we would definitely would want to be selling to the customers that are giving us the business, which is not only the low value, but also either there’s a portfolio which combines the low-value test with the high-value testing, and then that becomes more positive for us.

But if a client is only giving us a low order value test, then this is a natural shift that we do not want to be kind of taking over that particular business. And that’s where we are looking at more carefully as, okay, what are those tests that we would want to be in? So from the margin standpoint, in the long term, as we kind of shift towards the high value, high margin test, that will definitely be accretive to our growth margins as we’re kind of also going to be able to improve our operational efficiencies using our lab infrastructure.

Speaker 2: Thank you. Okay.

Kelly, Conference Call Operator: Thank you. This does conclude today’s question and answer session. I’d now like to turn the floor back over to Tony Zook.

Tony Zook, Chief Executive Officer, NeoGenomics: I’d just like to thank everybody for joining us on the call, and I’d also like to thank our roughly 2,400 teammates for their unwavering commitment to our mission and their hard work throughout all of 2025. I’m very excited for the year ahead for our company, our oncology physician customers, and their patients. I look forward to our next quarterly update in April, where we’ll report our first quarter results. Thank you again, and have a great day.

Kelly, Conference Call Operator: Thank you, everyone. This does conclude today’s conference call. You may disconnect your phone lines at this time and have a wonderful day. Thank you for your participation.