Insider Trading April 21, 2026 04:58 PM

Rapport Therapeutics CDO Disposes $808,844 in Shares; Company Advances RAP-219 Toward Phase 3

Sale executed under a Rule 10b5-1 plan as clinical data and analyst Buy ratings coincide with accelerated development timelines

By Nina Shah RAPP
Rapport Therapeutics CDO Disposes $808,844 in Shares; Company Advances RAP-219 Toward Phase 3
RAPP

Yeleswaram Krishnaswamy, Chief Development Officer of Rapport Therapeutics, sold 20,225 shares on April 17, 2026, for $808,844 under a pre-existing Rule 10b5-1 plan. The stock traded between $39.90 and $40.38 on the day of the sale and is currently at $36.95. Separately, the company reported strong Phase 2a results for RAP-219 and announced plans to move to Phase 3 studies in the second quarter of 2026; several brokerages have reiterated Buy ratings with varying price targets.

Key Points

  • CDO Yeleswaram Krishnaswamy sold 20,225 shares on April 17, 2026, for $808,844 under a Rule 10b5-1 plan and now holds 246,426 shares.
  • Rapport’s stock traded between $39.90 and $40.38 on the sale date, is currently $36.95, is up 258% over the past year, and has a market cap of $1.78 billion.
  • Rapport plans to advance RAP-219 to Phase 3 in Q2 2026 after Phase 2a results showing a 90% median seizure reduction in weeks 9-12 and 59% in weeks 13-16; Truist, Stifel, and Jones Trading have reiterated Buy ratings with price targets of $44, $56, and $50.

Insider sale details

Yeleswaram Krishnaswamy, Chief Development Officer at Rapport Therapeutics, Inc. (NASDAQ: RAPP), sold 20,225 shares of the company’s common stock on April 17, 2026. The disposition generated proceeds totalling $808,844, with the shares transacted at prices ranging from $39.90 to $40.38. Following the sale, Mr. Krishnaswamy directly holds 246,426 shares of Rapport common stock.

The sales were carried out under a Rule 10b5-1 trading plan that Mr. Krishnaswamy established on December 10, 2025. On the date of this report, Rapport’s share price has moved to $36.95. The company’s market capitalization is reported at $1.78 billion and the stock is up 258% over the past year.


Valuation and analyst context

According to InvestingPro analysis cited in the company’s reporting, the stock currently appears overvalued versus its Fair Value estimate. The InvestingPro platform is noted to provide additional ProTips and a suite of financial metrics for investors preparing for Rapport’s May 7 earnings report.


Clinical progress for RAP-219

Rapport Therapeutics has reported promising clinical data from its Phase 2a trial of RAP-219, an investigational therapy for epilepsy. During the trial follow-up period, patients experienced a median 90% reduction in seizures during weeks 9-12 and a 59% reduction in weeks 13-16 compared with baseline measurements. The company plans to present these results at the 2026 American Academy of Neurology Annual Meeting.

In response to the Phase 2a data, Rapport announced plans to initiate Phase 3 trials for RAP-219 in the second quarter of 2026, moving the program forward ahead of the company’s original schedule. The planned Phase 3 studies are expected to enroll approximately 320 patients per study and will test various dosages over a 14-week treatment period.


Market reaction and broker outlook

Following the accelerated development timeline and the release of fiscal 2025 results, three brokerages - Truist Securities, Stifel, and Jones Trading - each reiterated a Buy rating on Rapport Therapeutics. The firms published price targets of $44.00, $56.00, and $50.00, respectively.


What to watch next

Key near-term events include Rapport’s May 7 earnings report and the company’s planned transition to Phase 3 testing for RAP-219 in the second quarter. Investors monitoring valuation metrics, clinical readouts, and upcoming corporate disclosures will likely use those data points to reassess the company’s outlook.

This article reports the company-disclosed transaction, clinical results, analyst ratings, and planned trial details without adding external commentary or speculation.

Risks

  • Valuation risk - InvestingPro analysis indicates the stock presently appears overvalued relative to its Fair Value, which could affect investor returns and market sentiment.
  • Clinical development risk - While Phase 2a results were reported as promising, future outcomes from the planned Phase 3 studies (approximately 320 patients per study over 14 weeks) remain uncertain.
  • Market volatility following insider selling and near-term corporate events - The insider sale, upcoming May 7 earnings report, and the transition to Phase 3 introduce potential short-term share price volatility.

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